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KMID : 0811720000040010055
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Korean Journal of Physiology & Pharmacology
2000 Volume.4 No. 1 p.55 ~ p.62
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Effects of Norepinephrine and Neuropeptide Y on the Contractility of Small Mesenteric Artery from 2K1C and DOCA-Salt Hypertensive Rats
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Sang Chae Nam/Sang Chae Nam
Seongsu Kang/Wonjae Kim/Jongun Lee
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Abstract
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The present study was conducted to investigate the possible role of the sympathetic nervous system in two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension. 2K1C and DOCA- salt hypertension were made in Sprague-Dawley rats. Four weeks after induction of hypertension, systolic blood pressure measured in conscious state was significantly higher in 2K1C (216±18mmHg) and DOCA-salt (205±29mmHg) groups than that in control (128±4mmHg). The third branches (＜300 μm in outer diameter) of the mesenteric artery were isolated and cut into ring segments of 2∼3 mm in length. Each ring segment was mounted in tissue bath and connected to a force displacement transducer for measurement of isometric tension. The arterial rings were contracted by application of norepinephrine (NE) in a dose-dependent manner. The amplitude of the NE-induced contraction of the vessels was significantly larger in hypertension than in control. The NE-induced contraction was significantly enhanced by neuropeptide Y (NPY) in hypertension. Reciprocally, NPY-elicited vasocontraction was increased by NE in hypertension. These results suggest that the sympathetic nervous system contributes to the development of 2K1C and DOCA-salt hypertension.
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KEYWORD
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